Correlation between QCT and QCA with FFR measurement was weak (R values of -0.32 and -0.30, respectively). The diagnostic accuracy of CTCA, QCT, CCA, and QCA to detect a hemodynamically significant coronary lesion was 49%, 71%, 61%, and 67%, respectively. Stented segments and bypass grafts were not included in the analysis.Ī total of 89 stenoses were evaluated of which 18% (16 of 89) had an FFR <0.75. A significant anatomical or functional stenosis was defined as >/=50% diameter stenosis or an FFR <0.75. CTCA and conventional coronary angiography (CCA), and QCT and quantitative coronary angiography (QCA), were performed to determine the severity of a stenosis that was compared with FFR measurements. We investigated 79 patients with stable angina pectoris who underwent both 64-slice or dual-source CTCA and FFR measurement of discrete coronary stenoses. It has been demonstrated that CTCA provides excellent diagnostic sensitivity for identifying coronary stenoses, but may lack accurate delineation of the hemodynamic significance. We sought to determine the diagnostic accuracy of noninvasive visual (computed tomography coronary angiography ) and quantitative computed tomography coronary angiography (QCT) to predict the hemodynamic significance of a coronary stenosis, using intracoronary fractional flow reserve (FFR) as the reference standard.
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